Comments on: FDA Raises The Bar For New Diabetes Drugs http://www.pissd.com/2008/12/fda-raises-the-bar-for-new-diabetes-drugs/ About the ways injured and disabled persons are mistreated by governments and insurance companies. Fri, 10 Feb 2012 16:49:16 -0600 http://wordpress.org/?v=2.8 hourly 1 By: Aaron Novack http://www.pissd.com/2008/12/fda-raises-the-bar-for-new-diabetes-drugs/comment-page-1/#comment-235 Aaron Novack Fri, 19 Dec 2008 19:28:52 +0000 http://workshop.g2webmedia.com/bobk/uncategorized/fda-raises-the-bar-for-new-diabetes-drugs/#comment-235 This is why the news media shouldn't be reporting on Science and Drugs, because they mislead the public. There is nothing inherent in Diabetes treatments that raise the risk of heart attacks. It is a target specific effect. For example Avandia is a PPAR gamma agonist and the heart risk comes from agonizing this particular target. When you move to other therapies that treat the disease through agonizing or antagonizing different targets (such as raising GLP-1) you may not have the same effect. Drugs need to be taken in context, you just can't claim that all treatments are the same. In article Metformin seems to get a pass (they call it a pill which is somehow different from Avandia which is a what????) and this is because it acts on a different target. This misinformation is not helpful. This is why the news media shouldn’t be reporting on Science and Drugs, because they mislead the public. There is nothing inherent in Diabetes treatments that raise the risk of heart attacks. It is a target specific effect. For example Avandia is a PPAR gamma agonist and the heart risk comes from agonizing this particular target. When you move to other therapies that treat the disease through agonizing or antagonizing different targets (such as raising GLP-1) you may not have the same effect. Drugs need to be taken in context, you just can’t claim that all treatments are the same. In article Metformin seems to get a pass (they call it a pill which is somehow different from Avandia which is a what????) and this is because it acts on a different target. This misinformation is not helpful.

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